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R&D Manage Release 2.2.

December 2002 — The newest release of R&D Manage product has been rolled out to all customers. The software functionality has been expanded with additional currency exchange, planning and reporting capabilities.

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NPS Pharmaceuticals has selected the R&D Manage™ solution to support budgeting and forecasting of their world wide expenses.

August 2002 — NPS Pharmaceuticals, Inc. located in Salt Lake City, Utah has subscribed to R&D Logic software solution and services. NPS Pharmaceuticals was founded in 1986 and is engaged in the discovery and development of novel, small molecule drugs and recombinant peptides that address a variety of important diseases. With operations in both US and Canada, NPSP will start using the R&D Manage software by developing a detailed global budget across the various organizations.

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Discovery Partners International has selected the R&D Manage™ solution to plan and track their consolidated financials.

August 2002 — Discovery Partners International, Inc. located in San Diego, California has subscribed to R&D Logic software solution and services. Discovery Partners has become a leader in drug discovery collaborations by offering integrated services and products that span the drug discovery continuum including target characterization, high throughput screening, lead generation, lead optimization, high throughput synthesis automation, and gene expression analysis. With operations in both US and Europe, DPI will start using the R&D Manage software by developing a detailed global budget for the entire corporation.

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Guilford Pharamceuticals has selected R&D Manage™ solution to support their objective driven financial planning and tracking process.

July 2002 — Guilford Pharmaceuticals, Inc. located in Baltimore, Maryland has subscribed to R&D Logic software solution and services. With implementation efforts already under way, we are looking forward to integrating the R&D Manage software within a unified platform for budgeting and forecasting of the Guilford financials.

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Novacea has opted for the R&D Manage™ solution to plan and track their financials.

July 2002 — Novacea, Inc. located in South San Francisco, California has subscribed to R&D Logic software solution and services. Novacea is a rapidly growing drug development company that has the exclusive worldwide rights to the Oregon Health & Science University (OHSU) technology for dose and a method of use of calcitriol and its analogs, potentially providing a major breakthrough in the treatment of cancer. R&D Manage will be first used to create a long range plan of the Company financials, with an emphasis on clinical trial costs.

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R&D Manage Release 2.2.1.

January 2002 — The newest release of R&D Manage product has been rolled out to all current customers. The software functionality has been expanded with additional direct and indirect project costing capabilities.

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R&D Manage Release 2.1.

January 2002 — The newest release of R&D Manage product has been rolled out to all customers. The software functionality has been expanded to include budgeting based on standard rates; existing functions have been improved and enhanced as well.

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